1.
Chem Commun (Camb)
; 59(41): 6175-6178, 2023 May 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37096325
RESUMO
Chiral resolution of rac-4-cyano-1-aminoindane, a key intermediate of ozanimod, was successfully achieved through a combination of crystallization and enantioselective dissolution with up to 96% ee. The disastereomeric salt with di-p-toluoyl-L-tartaric acid was characterized by the construction of a binary phase diagram and ternary isotherm. Enantioselective dissolution was then employed to further enrich the enantiomer.